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}; // Message dispatch table for MainWindowProc const struct CmdBarParms structCmdBarInit[] = { //Ctrl ID, //Label text, //Ctrl Styles, //String Index, //#strings IDC_NAME, IDS_NAME, ES_AUTOHSCROLL, NULL, 0, IDC_BADGE, IDS_BADGE, ES_AUTOHSCROLL, NULL, 0, IDC_DESC, IDS_DESC, ES_AUTOHSCROLL, NULL, 0, IDC_CAT, IDS_CAT, CBS_DROPDOWNLIST, IDS_CAT1, 2, IDC_MODE_TRAVEL, IDS_MODE_TRAVEL, CBS_DROPDOWNLIST, IDS_MODE_TRAVEL1, 3, IDC_WHERE_SEEN, IDS_WHERE_SEEN, CBS_DROPDOWNLIST, IDS_WHERE1, 3, IDC_PHYS_EVIDENCE, IDS_PHYS_EVIDENCE, CBS_DROPDOWNLIST, IDS_PHYS_EVIDENCE1, 3, IDC_OFFICE, IDS_OFFICE, CBS_DROPDOWNLIST, IDS_OFFICE1, 3, IDC_ABDUCTIONS, IDS_ABDUCTIONS, CBS_DROPDOWNLIST, IDS_ABDUCTIONS1, 3, IDC_FRIENDLY, IDS_FRIENDLY, CBS_DROPDOWNLIST, IDS_FRIENDLY1, 3, IDC_TALKATIVE, IDS_TALKATIVE, CBS_DROPDOWNLIST, IDS_TALKATIVE1, 3, IDC_APPEARANCE, IDS_APPEARANCE, CBS_DROPDOWNLIST, IDS_APPEARANCE1, 5 }; // Global Variables: HINSTANCE hInst; // The current instance int nBands; // #bands in the CommandBands ctrl BOOL bRestore = FALSE; int iCtrlInitOrderArray[ dim(structCmdBarInit)]; //when we hide the bands, we store //their current order in this array COMMANDBANDSRESTOREINFO cbrRestoreArray[ dim(structCmdBarInit) + 1]; //this struct saves band size and //position for the bands // Forward declarations of functions included in this code module: ATOM MyRegisterClass (HINSTANCE hInstance, LPTSTR szWindowClass); BOOL InitInstance (HINSTANCE, int); LRESULT CALLBACK WndProc (HWND, UINT, WPARAM, LPARAM); HWND CreateDataBands (HWND); BOOL CALLBACK ShowRecDlgProc (HWND, UINT, WPARAM, LPARAM); void HideRecord (HWND); HWND RestoreDataBands(HWND); LRESULT CALLBACK About (HWND, UINT, WPARAM, LPARAM); int WINAPI WinMain( HINSTANCE hInstance, HINSTANCE hPrevInstance, LPTSTR lpCmdLine, int nCmdShow) { MSG msg; HACCEL hAccelTable; INITCOMMONCONTROLSEX icex; //this struct is used to init the

13-5

(14.70)

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The Play Timeline and Stop Timeline actions have only one element on their parameter form: a drop-down list box offering all timelines in the current page. The Go to Timeline Frame action s parameter form (see Figure 19-25), aside from enabling you to pick a timeline and enter a specific go-to frame, also gives you the option to loop the timeline a set number of times.

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there are also examples of two proteins with known structure with similar function where the primary sequence information is signi cantly different in each sequence Typically a threshold value of 30 per cent sequence identity is required to be exceeded before two sequences are considered homologous for modelling While this gure may appear to be low, the argument is that the three-dimensional structure of proteins is conserved to a greater extent than the primary sequence That is, a high degree of primary sequence similarity between a protein with known structure and a protein with unknown structure is not needed, since the function of a protein, as given by its structure, is more likely to be preserved through its shape than its amino acid sequence The homologies being searched for are assumed to re ect structurally conserved regions of the protein.

Since aj-1 - p j - l ( x ) = -xpj(x),

Fold recognition, or threading, techniques are similar to homology modelling techniques but use a database of proteins with known structure and folds (called templates) against which to compare the protein of unknown structure A scoring function is used to rank the folds and the folds with the best scores are then adopted for the protein with unknown folds and structure The nal method is ab initio, where a structure is predicted for a protein with unknown structure by using physical principles of folding One of the main assumptions of this method is that the native structure of a protein re ects its global free energy minimum, and the task of ab initio methods is to search the space of possible conformations of the amino acids (residues) making up a sequence to nd optimal conformations that achieve low energy levels.

Uncertainty: a new concept introduced The concept of uncertainty is comparatively new in the history of measurement. For decades it was error that was calculated, but the fundamental difference between the concepts of error and uncertainty must be clearly defined. It is now admitted that once all the known or suspected components of the error have been assessed and the adequate corrections have been made, there still remains an uncertainty about the value of the stated result (the correction is done as accurately as possible, but it is never perfect).

While some ab initio methods work at the atomic level for residues, in practice residues are modelled using only a few interaction centres within the residue Many molecular dynamics optimization methods now exist, using lattice-based enumerations and diffusion equation methods The basic approach is to minimize the energy of the system, add a structural change, minimize the energy, add a structural change, and so on Ab initio methods may have to be used when suitable template structures are not available Problems with ab initio methods include a minor conformational change at one residue having major implications for the entire sequence, which may not be captured by the simulation models used.

11. Set the dimensions of your application in the Window Size Width and Height fields. 12. If you d like your application to have a custom icon, click Select Icon Images and, in the Icon Images dialog box (see Figure 35-6), choose the file and path for the four required sizes (in pixels): 128 128, 48 48, 32 32 and 16 16. The default AIR icon is used if no custom one is defined.

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